Nearly Four Decades of Excellence in Pharmacokinetics Education

For nearly four decades, this rigorous yet accessible course in pharmacokinetics has been attended by more than 2,700 pharmaceutical scientists worldwide. The course has long served as a foundation for scientists new to pharmacokinetics, as well as a structured refresher for those with prior experience.

In 2025, the course was intentionally paused to allow for a comprehensive revision of both content and teaching approach. The goal: simplifying how pharmacokinetics is taught and applied in drug development, with particular emphasis on drug dosing decisions as a function of disease states, drug-drug interactions, and pharmacogenomic and physiologic variables.

The Benet Lab has published 13 peer-reviewed manuscripts since 2022 describing and evaluating this streamlined teaching approach.

  • 38 Years

    Teaching Excellence

  • 2,700+

    Alumni Trained

  • 90 Spots

    Available

  • 13 Papers

    Published Since 2022

A Completely Revised Approach

This rigorous yet accessible course in pharmacokinetics has trained more than 2,700 pharmaceutical scientists worldwide over its 38-year history. The course has long served as a foundation for scientists new to pharmacokinetics, as well as a structured refresher for those with prior experience.

In 2025, the course was intentionally paused to allow for a comprehensive revision of both content and teaching approach. The goal: simplifying how pharmacokinetics is taught and applied in drug development, with particular emphasis on drug dosing decisions as a function of disease states, drug-drug interactions, and pharmacogenomic and physiologic variables. The Benet Lab has published 13 peer-reviewed manuscripts since 2022 describing and evaluating this streamlined teaching approach.

Course Format

  • 7 Benet Live Lectures with Open Discussion

    Real-time questions and discussion with Dr. Benet. Lecture slides emailed prior to each session.

  • 7 Interactive Workshops

    Small group format led by currently active industrial scientists and academic faculty, all trained in the Benet Lab. Completely new workshop problems.

  • 2 Further Lectures Previously Present in the UCSF Course

    Expert presentations on PK/PD Modeling and Macromolecular Pharmacokinetics.

  • Fully Virtual Format

    Attend from anywhere. Materials emailed before each session. Answer keys distributed after each workshop.

The New Findings: Beyond Traditional Teaching

This new methodology provides the same analysis and application of pharmacokinetics as has been taught for the past 100 years—but without requiring differential equation derivations and mechanistic assumptions.

More importantly, the new methodology explains data previously unexplained and often thought to be in error, including:

- Importance of including blood flow in clearance derivations
- Understanding when Foral, systemic > 1.0
- Why renal clearance can change due to input
- Explaining why equivalent doses of extended release vs immediate release dosage forms may give increased pharmacodynamic outcomes
- A paradigm shift in drug development that potentially can lead to increased efficacy and decreased toxicity

This course is appropriate for pharmaceutical scientists with little or no formal training in PK, scientists working in adjacent disciplines who use PK concepts, and experienced pharmacokineticists interested in a streamlined and integrated framework.

Detailed Course Schedule

ALL TIMES PACIFIC DAYLIGHT TIME (PDT)

Day 1 - Wednesday, April 29

8:00-8:15 AM - Introduction

8:15-9:30 AM - Lecture 1 (Dr. Benet)
Deriving Renal and Hepatic Clearance Following IV Bolus Dosing

9:30-9:45 AM - Break

9:45-11:30 AM - Workshop 1

11:30 AM-12:00 PM - Break

12:00-1:00 PM - Lecture 2 (Dr. Benet)
Drug Input, Mean Residence Time, Bioavailability, Volumes of Distribution

1:05-2:50 PM - Workshop 2

Day 2 - Thursday, April 30

8:00-9:00 AM - Lecture 3 (Dr. Benet)
Protein Binding, Expanding MRT Concepts, Dissolution

9:00-9:15 AM - Break

9:15-10:45 AM - Workshop 3

10:45-11:00 AM - Break

11:00 AM-12:30 PM - Lecture 4 (Dr. Benet)
Half-Life, Multiple Dosing Equations, Accumulation

12:30-1:00 PM - Break

1:00-2:30 PM - Workshop 4

Day 3 - Friday, May 1

8:00-9:15 AM - Lecture 5 (Dr. Benet)
PBPK and Clearance Measures, Saturable Kinetics, BCS, BDDCS and ECCS

9:15-9:30 AM - Break

9:30-11:00 AM - Workshop 5

11:00-11:15 AM - Break

11:15 AM-12:30 PM - Lecture 6 (Dr. Benet)
Renal Clearance Complications, Mechanistic Models, The New Findings

12:30-1:00 PM - Break

1:00-2:30 PM - Workshop 6

Day 4 - Saturday, May 2

8:00-9:15 AM - PK/PD Modeling Lecture
Dr. James A. Uchizono, Professor and Associate Dean, University of the Pacific

9:15-9:30 AM - Break

9:30-10:30 AM - Macromolecular Pharmacokinetics Lecture
Dr. Sara Kenkare-Mitra, Former Senior Vice President, Drug Development, Genentech

10:30-10:45 AM - Break

10:45 AM-12:45 PM - Workshop 7

12:45-1:15 PM - Break

1:15-2:15 PM - Lecture 7 (Dr. Benet)
Review of Basic Concepts

Dr. Leslie Z. Benet in his laboratory, course director for Pharmacokinetics for Pharmaceutical Scientists

Led by Dr. Leslie Z. Benet

Dr. Leslie Z. Benet is Professor Emeritus of Bioengineering and Therapeutic Sciences, and Pharmaceutical Chemistry. He has been awarded 9 Honorary Doctorates and is one of the most highly cited DMPK scientists worldwide.

With 632 peer-reviewed publications, an H-factor of 91 (Clarivate Analytics), and over 38,000 citations, Dr. Benet has shaped the field of pharmacokinetics for decades. His Google Scholar metrics show an H-factor of 110 with over 66,000 citations.

Dr. Benet led the pharmacokinetics course for pharmaceutical scientists for more than 30 years and has pioneered the revolutionary physics-based approach that forms the foundation of this revised curriculum.

Expert Workshop Leaders

  • Dr. Christine Bowman, Principal Scientist, Drug Metabolism and Pharmacokinetics, Genentech

    Dr. Christine Bowman

    Principal Scientist, Drug Metabolism and Pharmacokinetics, Genentech

  • Dr. Jasleen K. Sodhi, Director, DMPK and Clinical Pharmacology, Septerna Inc.

    Dr. Jasleen K. Sodhi

    Director, DMPK & Clinical Pharmacology, Septerna, Inc.

  • Dr. Marc Anthony R. Yago

    Scientific Associate Director, Clinical Pharmacology, Modeling & Simulation, Amgen, Inc.

  • Dr. David Lau

    Vice President, DMPK & Clinical Pharmacology, Septerna, Inc.

  • Dr. Justine Lam

    Executive Director, Clinical Pharmacology.  Erasca Inc.

  • Dr. Miki Park, pharmacokinetics guest lecturer, Benet PK Course faculty

    Dr. Miki Susanto Park

    Professor of Pharmaceutical Sciences, University of the Pacific

  • Dr. Jae Chang

    Senior Director, Drug Metabolism and Pharmacokinetics, Gilead

  • Dr. Chi-Yuan Wu

    Executive Director of Clinical Pharmacology, Topalliance Biosciences

  • Dr. Shufang Liu

    Manager, Quantitative Clinical Pharmacology, Precision Medicine, Daiichi Sankyo Inc.

  • Dr. Laurent Salphati

    Senior Fellow, Drug Metabolism and Pharmacokinetics, Genentech, Inc.

  • Dr. Maribel Reyes

    VP, Clinical Pharmacology and Translational Science, Korsana Biosciences

  • Dr. Carolyn Cummins

    Associate Professor

    Associate Scientific Director, PRiME

    Director, Collaborative Specialization in Next-Generation Precision Medicine

    Leslie Dan Faculty of Pharmacy University of Toronto

Additional Lecturers

Pharmacokinetic-Pharmacodynamic Modelling

James A. Uchizono, PharmD, PhD, Professor and Associate Dean, University of the Pacific

James A. Uchizono

PharmD, PhD, Professor and Associate Dean, University of the Pacific

Macromolecular Pharmacokinetics

Sara Kenkare-Mitra, PhD, Adjunct Professor of Bioengineering and Therapeutic Sciences, UCSF

Sara Kenkare-Mitra

PhD, Adjunct Professor of Bioengineering and Therapeutic Sciences, UCSF

Past President and Head of Research and Development, Alector
Past Senior Vice President, Development Sciences, Genentech

Is This Course Right for You?

  • Perfect For

    - Pharmaceutical scientists with little or no formal training in PK

    - Scientists working in adjacent disciplines who use PK concepts

    - Experienced pharmacokineticists interested in a streamlined and integrated framework

    - Research teams focused on ADME studies

    - Drug development professionals making dosing decisions

  • What You'll Gain

    - New physics-based methodology for PK analysis without differential equations

    - Practical hands-on workshop experience with completely new problem sets

    - Direct Q&A access with Dr. Benet during lectures

    - Comprehensive answer sheets for all workshop problems

    - All materials and slides delivered before each session

    - Insights from leading industry scientists and academics

    - Certificate of completion

Limited to 90 Participants

Registration is first-come, first-served.

Registration Fee: $900
(No discounts available)

Questions? Email info@benetpkcourse.com

Register Now