Nearly Four Decades of Excellence in Pharmacokinetics Education

For nearly four decades, this rigorous yet accessible course in pharmacokinetics has been attended by more than 2,700 pharmaceutical scientists worldwide. The course has long served as a foundation for scientists new to pharmacokinetics, as well as a structured refresher for those with prior experience.

  • 39 Years

    Teaching Excellence

  • 2,700+

    Alumni Trained

  • 90 Spots

    Available per course

  • 13 Papers

    Published Since 2022

Choose your course

Each regional course follows the same four-day curriculum, taught on local time by Dr. Benet and regional tutors. Pick the course that fits your time zone.

Registration Open

Europe 2026

Live online, taught on Central European Time.
Register for EU
Dates To Be Announced

United States 2027

Live online, taught on US Pacific Time.
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A Completely Revised Approach

In 2025, the course was intentionally paused to allow for a comprehensive revision of both the content and teaching approach. The goal: simplifying how pharmacokinetics is taught and applied in drug development, with particular emphasis on drug dosing decisions in drug development for initial drug approval and as applied in labeling and application to drug dosing decisions as a function of disease states, drug-drug interactions, and pharmacogenomic and physiologic variables. The Benet Lab has published 13 peer-reviewed manuscripts since 2022, including invited presentations in Pharmacological Reviews and Annual Review of Pharmacology and Toxicology, describing and evaluating this streamlined teaching approach. The new approach was first taught in the UCSF graduate pharmacokinetics course in Fall 2025 and then in its present online format, April 29 to May 2, 2026, in US time zones to 77 registrants.

Course Format

  • 7 Benet Live Lectures with Open Discussion

    Real-time questions and discussion with Dr. Benet. Lecture slides emailed prior to the course. Recordings of lectures will not be provided, but registrants are free to record the lectures for their own use.

  • 7 Interactive Workshops

    Small group format led by currently active industrial scientists and academic faculty, all trained in the Benet Lab. Completely new workshop problems.

  • 2 Further Lectures Previously Present in the UCSF Course

    Expert presentations on PK/PD Modeling and Macromolecular Pharmacokinetics.

  • Fully Virtual Format

    Attend from anywhere. Materials emailed before the course begins. Answer keys distributed after each workshop.

The New Findings: Beyond Traditional Teaching

This new methodology provides the same analysis and application of pharmacokinetics as has been taught for the past 100 years, but without requiring differential equation derivations and mechanistic assumptions.

More importantly, the new methodology explains data previously unexplained and often thought to be in error, including:

  • Importance of including blood flow in clearance derivations
  • Understanding when Foral, systemic > 1.0
  • Why renal clearance can change due to input
  • Explaining why equivalent doses of extended release vs immediate release dosage forms may give increased pharmacodynamic outcomes
  • A paradigm shift in drug development that potentially can lead to increased efficacy and decreased toxicity

This course is appropriate for pharmaceutical scientists with little or no formal training in PK, scientists working in adjacent disciplines who use PK concepts, and experienced pharmacokineticists interested in a streamlined and integrated framework. Pharmacokinetics is the mathematics of drug therapy, the emphasis of this course rather than the methodology utilized to generate the experimental data.

Detailed Course Schedule

Structure is the same across regional courses. See each course page for local time zones.

Day 1

Introduction

Lecture 1 (Dr. Benet): Deriving Renal and Hepatic Clearance Following IV Bolus Dosing

Break

Workshop 1

Break

Lecture 2 (Dr. Benet): Drug Input, Mean Residence Time, Bioavailability, Volume of Distribution

Workshop 2

Day 2

Lecture 3 (Dr. Benet): Protein Binding, Expanding MRT Concepts, Dissolution

Break

Workshop 3

Break

Lecture 4 (Dr. Benet): Half-Life, Multiple Dosing Equations, Accumulation

Break

Workshop 4

Day 3

Lecture 5 (Dr. Benet): PBPK and Clearance Measures, Saturable Kinetics, BCS, BDDCS and ECCS

Break

Workshop 5

Break

Lecture 6 (Dr. Benet): Renal Clearance Complications, Mechanistic Models, The New Findings

Break

Workshop 6

Day 4

PK/PD Modeling Lecture: Dr. James A. Uchizono, Professor and Associate Dean, University of the Pacific

Break

Macromolecular Pharmacokinetics Lecture: Dr. Sara Kenkare-Mitra, Former Senior Vice President, Drug Development, Genentech

Break

Workshop 7

Break

Lecture 7 (Dr. Benet): Review of Basic Concepts

What students say

Selected comments from registrants who attended the Spring 2026 course.

"The Lectures and Workshops served as an excellent resource to help better understand Pharmacokinetics from a beginner's perspective. The examples discussed made the course very engaging even for complex topics. Specifically, reiteration of key points during lectures was a great help in connecting various aspects allowing concepts to be grasped easily."

"I really enjoyed the course and workshop. The content was intensive, but the depth of expertise that Prof. Benet and my Workshop tutors brought to the sessions was truly remarkable. Their ability to engage with us and clarify complex concepts within just a few days was marvelous. I gained so many valuable takeaways, and the fundamental knowledge I acquired in this field has been incredibly enriching and inspiring. Thank you very much for such an outstanding learning experience!"

"Overall, I feel that I learned enough from the course to better understand (i) the language of PK, (ii) how my DMPK colleagues derive these parameters, and (iii) how these parameters describe a molecule's exposure in vivo and its likelihood to elicit a desired PD effect."

"Despite this being pretty fast for me, I deeply appreciated the course and it has given me a better perspective on PK in that I can at least understand and contribute (asking better questions) to clin pharmacology teammates as we navigate the early development world together. Thank you so much for your passion and enthusiasm for teaching PK and challenging the norm! It's been an honor to attend this course."

"I want to thank Professor Benet and Dr. Sodhi for an incredible course. Professor Benet is a true architect of pharmacokinetics; it was a profound honor to learn from someone who didn't just study the field but actively defined its boundaries. His ability to connect the historical evolution of PK with innovative concepts, like the application of Kirchhoff's Laws, is a testament to his enduring brilliance. This experience was a highlight of my professional education."

Dr. Leslie Z. Benet in his laboratory, course director for Pharmacokinetics for Pharmaceutical Scientists

Led by Dr. Leslie Z. Benet

Dr. Leslie Z. Benet is Professor Emeritus of Bioengineering and Therapeutic Sciences, and Pharmaceutical Chemistry. He has been awarded 9 Honorary Doctorates and is one of the most highly cited DMPK scientists worldwide.

With 632 peer-reviewed publications, an H-factor of 91 (Clarivate Analytics), and over 38,000 citations, Dr. Benet has shaped the field of pharmacokinetics for decades. His Google Scholar metrics show an H-factor of 110 with over 66,000 citations.

Dr. Benet led the pharmacokinetics course for pharmaceutical scientists for nearly four decades and has pioneered the revolutionary physics-based approach that forms the foundation of this revised curriculum.

Is This Course Right for You?

  • Perfect For

    - Pharmaceutical scientists with little or no formal training in PK

    - Scientists working in adjacent disciplines who use PK concepts

    - Experienced pharmacokineticists interested in a streamlined and integrated framework

    - Research teams focused on analyzing ADME study data

    - Drug development professionals making dosing decisions

  • What You'll Gain

    - New physics-based methodology for PK analysis without differential equations

    - Practical hands-on workshop experience with completely new problem sets

    - Direct Q&A access with Dr. Benet during lectures

    - Comprehensive answer sheets for all workshop problems

    - All materials and slides delivered prior to the course

    - Insights from leading industry scientists and academics

    - Certificate of completion

Limited to 90 Participants per course

Registration is first-come, first-served.

Registration Fee: $900
(No discounts available)

Questions? Email info@benetpkcourse.com

Register